Michael Webb
Associate Professor of Chemistry (Inorganic)
ISC 327C
(585)245-5314
mwebb@geneseo.edu
he/him
Dr. Michael Webb has been a member of the 第一吃瓜网 faculty since 2022.
Research Interests
Research within the Webb group focuses on the occurrence of metals in medicine as either the therapeutic agent or the target for therapy. Specifically, protein interactions have been observed to be central in either the pathology of several diseases following an interactions with endogenous metal ions, thereby becoming the target for therapy, or in the transportation of metallotherapeutics to their site of action. The projects we are currently investigating are: (1) the use of ruthenium-based therapeutics for the treatment of Alzheimer檚 disease, (2) ruthenium complexes as antibacterial agents, and (3) the interactions between metal ions and the Parkinson檚 disease protein. For more information on these projects, please visit my personal research webpage: https://webb-lab.weebly.com/
Office Hours
Curriculum Vitae
Education
Postdoctoral Researcher, University of California Berkeley, Berkeley, CA.
Ph.D. Chemistry, Simon Fraser University, Burnaby, BC.
B.Sc. Chemistry (Honours), Mount Allison University, Sackville, NB.
Publications
第一吃瓜网 Student Co-authors are in听bold
11.听Murphy, B.J.�;听Bollinger, T.A.�; Dagar, M.;听Hacker, R.M.; Oskard, S.M.; Brennessel, W.W.; Webb, M.I. 淭wo Perfectly Cromulent Ferrocene Containing Ruthenium(II)-arene Antibacterial Agents澨�Canadian Journal of Chemistry,听2025, In Press (� = each author contributed听equally to this work).
10.听Hacker, R.M.;听Smith, J.J.; Platt, D.C.; Jones, M.A.; Brennessel, W.W.; Webb, M.I. 淩uthenium(II)-Arene Complexes with a 2,2′-Bipyridine Ligand as Anti-A尾 Agents澨�Biomolecules,听2025, 15, 475.
9.听Hacker, R.M.;听Grimard, D.M.;听Morgan, K.A.; Saleh, E.; Wrublik, M.M.; Meiss, C.J.; Kant, C.C.; Jones, M.A.; Brennessel, W.W.; Webb, M.I. “Ru(ii)揳rene azole complexes as anti-amyloid-尾 agents”听Dalton Transactions,听2024, 53, 18845-18855.
8. Ehlbeck, J.T.;听Grimard, D.M.;听Hacker, R.M.; Garcia, J.A.; Wall, B.J.; Bothwell, P.J.; Jones, M.A.; Webb, M.I. “Finding the Best Location: Improving the Anti-Amyloid Ability of Ruthenium(III) Complexes with Pyridine Ligands”听Journal of Inorganic Biochemistry,听2024, 250, 112424.
7. Webb, M.I. (2023). The Design of Metal Complexes to Target the Amyloid-尾 Peptide in Alzheimer’s Disease. In Encyclopedia of Inorganic and Bioinorganic Chemistry, R.A. Scott (Ed.).
6. Mensah, S.; Rosenthal, J.D.; Dagar, M.; Brown, T.; Mills, J.J.; Hamaker, C.G; Ferrence, G.M.; Webb, M.I. 淎 Ru(II)-Arene-Ferrocene Complex With Promising Antibacterial Activity澨�Dalton Transactions,听2022, 51, 17609-17619.
5. Yawson, G.K.; Will, M.F.; Huffman, S. E.; Strandquist, E.T.; Bothwell, P.J.; Oliver, E.B.; Platt, D.C.; Apuzzo, C.F.; Weitzel, C.S.; Jones, M.A.; Ferrence, G.M.; Hamaker, C.G.; Webb, M.I. 淎 Dual-Pronged Approach: A Ruthenium(III) Complex That Modulates Amyloid-尾 Aggregation and Disrupts Its Formed Aggregates澨�Inorganic Chemistry,听2022, 61, 2733-2744.
4. Meiss, C.J.; Bothwell, P.J.; Webb, M.I. 淩uthenium(II)-Arene Complexes With Chelating Quinoline Ligands As Anti-Amyloid Agents澨�Canadian Journal of Chemistry,听2022, 100, 18-24.
3. Wall, B.J.�; Will, M.F.�; Yawson, G.K.; Bothwell, P.J.; Platt, D.C.; Apuzzo, C.F.; Jones, M.A.; Ferrence, G.M.; Webb, M.I. 淭he Importance of Hydrogen Bonding: Structure-Activity Relationships of Ruthenium(III) Complexes for Alzheimer檚 Disease Therapy with Pyridine-based Ligands澨�Journal of Medicinal Chemistry,听2021, 64, 10124-10138 (� = each author contributed equally to this work)
2. Yawson, G.K.; Huffman, S.E.; Fisher, S.S.; Bothwell, P.J.; Platt, D.C.; Jones, M.A.; Hamaker, C.G.; Ferrence, G.M.; Webb, M.I. 淩uthenium(III) Complexes with Imidazole Ligands That Modulate the Aggregation of the Amyloid-尾 Peptide Via Hydrophobic Interactions澨�Journal of Inorganic Biochemistry,听2021, 214, 111303.
1. Huffman, S.E.�; Yawson, G.K.�; Fisher, S.S.; Bothwell, P.J.; Platt, D.C.; Jones, M.A.; Hamaker, C.G; Webb, M.I. 淒etermining Structure Activity Relationships for Ruthenium(III) Complexes Containing Thiazole-based Ligands for Their Ability to Prevent Amyloid-Beta Aggregation澨�Metallomics,听2020, 12, 491-503. Featured on the back cover. (� = each author contributed equally to this work)